Further, structural dynamics are correlated to protein function because the missense-folding structure may result in protein dysfunction (Bromberg & Rost, 2009; Ponzoni & Bahar, 2018). If missense variants occur at the functional sites, it will change protein activity and binding affinity, resulting in diseases. Moreover, SAVs occurring at interfaces are also related to diseases, since it might ruin the network of protein-protein interaction (David, Razali, Wass, & Sternberg, 2012; Yates & Sternberg, 2013). At present, there are many large-scale studies; however, most of them focus on human genetic diseases (X. Wang et al., 2012).