Conclusion
Our study suggests that many women with FHA have a typical phenotype of
excessive cardiovascular exercise, weight loss, psychological stress and
reduced BMD. Psychological comorbidities including EDs, depression and
anxiety were moderately prevalent. The most effective parameters
distinguishing women with FHA from women with PCOS were low BMI,
estradiol, LH and LH:FSH ratio. These data could be utilized to
prospectively validate a standardized protocol to optimise the diagnosis
and improve the management of women with FHA.