3.4 Immunization with VLPs-ISPA and VLPs-CA induces a specific cellular immune response against FMDV in mice
At 36 dpv, when splenocytes were stimulated in vitro with inactivated virus, FMDV-specific T-cell stimulation levels were significantly higher in cells derived from mice immunized with VLPs-ISPA and VLPs-CA (p<0.05) or with the Commercial vaccine (p<0.001) than in those derived from VLPs, ISPA or PBS-inoculated mice (Figure 4).