Analysis of clinical characteristics and risk factors in
COVID-19 patients
Lu wen1,3,Yu Shuhui2,Hu
Ke3
1Department of respiratory disease, People’s Hosptial of Rizhao,
Affiliated Clinical Hospital of Jining Medical Univerity, Jining Medical
University, Rizhao, Shandong, China.
2 Department of Critical Care Medicine, Renmin Hospital of Wuhan
University, Wuhan, China.
Lu wen and Yu Shuhui contribute equally.
3 Division of Respiratory Disease, Renmin Hospital of Wuhan University,
Wuhan, China.
Electronic address:huke-rmhospital@163.com.
BACKGROUND: The aim of this study is to evaluate the clinical
characteristics and outcomes in 2019 novel coronavirus patients and to
help clinicians perform correct treatment and evaluate prognosis and
guide the treatment.
METHODS: 239 patients who were diagnosed with COVID-19 were
included in this study. Patients were divided into the improvement group
and the death group according to their outcome (improvement or
death).Clinical characteristics and laboratory parameters were collected
from medical records. Continuous variables were tested by independent
sample T test, and categorical variables were analyzed by chi-square
test or Fisher exact test. Cox proportional hazard regression model was
used for survival analysis in death patients.
RESULTS: Efficacy evaluation indicated that 99 patients
(41.4%) had deteriorated, and 140 patients (58.6%) had improved.
Oxygen saturation, hemoglobin levels, infection-related indicators,
lymphocyte and platelets counts, C-reactive protein, serum albumin,
liver and kidney function and lactate dehydrogenase in improvement group
were statistically significant between the improvement and death groups.
Survival analysis revealed that upper respiratory tract symptoms,
hypertension, pulmonary basic diseases, C-reactive protein,
lymphocyte counts,
albumin and blood urea
nitrogen were associated with
mortality risk in COVID-19.
CONCLUSION: Patients with older age, comorbidities, lower
lymphocyte counts
in hemogram and serum albumin,
high
c reactive protein
level and renal dysfunction may have higher risk to death. It warned us
that more attention should be given more attention on risk management in
the progression of COVID-19.
KEYWORDS: COVID-19; risk
factors of death; survival probability