Missing ethnic information in current BRCA variant databases
AbstractBRCA variation is highly ethnic-specific. Our analysis of major BRCA
reference databases shows that nearly all databases except BIC do not
provide ethnic information for their collected BRCA variants. We
consider that inclusion of ethnic information of BRCA variants is
necessary as it will benefit the study of human BRCA evolution,
understand ethnic-basis of BRCA variation and cancer, and promote
ethnic-based clinical applications in diversified ethnic populations.