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Innate Lymphoid Cells: The Missing Part Of A Puzzle In Food Allergy
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  • Umit Sahiner,
  • Janice Layhadi,
  • Kornel Golebski,
  • Zsolt Komlosi,
  • Yaqi Peng,
  • Bulent Sekerel,
  • Stephen Durham,
  • Helen Brough,
  • Hideaki Morita,
  • Mübeccel Akdis,
  • Paul Turner,
  • Kari Nadeau,
  • Hergen Spits,
  • Cezmi Akdis,
  • Mohamed Shamji
Umit Sahiner
Hacettepe University, School of Medicine
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Janice Layhadi
Imperial College London
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Kornel Golebski
Amsterdam UMC Locatie AMC
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Zsolt Komlosi
SIAF
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Yaqi Peng
Swiss Institute of Allergy and Asthma Research
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Bulent Sekerel
Hacettepe university
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Stephen Durham
NHLI, Imperial College
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Helen Brough
King's College London
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Hideaki Morita
University of Zurich
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Mübeccel Akdis
University of Zurich
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Paul Turner
Imperial College London
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Kari Nadeau
Stanford University
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Hergen Spits
Amsterdam University Medical Centres
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Cezmi Akdis
University of Zurich
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Mohamed Shamji
Imperial College London, Imperial College London
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Abstract

Food allergy is an increasingly common disease worldwide, and is thought to be driven by an uncontrolled type 2 immune response. Current knowledge about the underlying mechanisms that initiate and promote an inappropriate immune response to dietary allergens is limited. Sensitization through the skin in early life is considered to be a key event. Food allergy results from a dysregulated type 2 response to food allergens, characterized by enhanced levels of IgE, IL-4, IL-5 and IL-13 with infiltration of mast cells, eosinophils and basophils during acute reactions. Recent data implies a possible role of innate lymphoid cells (ILCs) in driving food allergy. ILCs represent a group of lymphocytes that lack specific, recombined antigen receptors. They contribute to immune responses not only through the release of cytokines and other mediators, but also by responding to cytokines produced by activated cells in their local microenvironment. Due to their localization at barrier surfaces of the airways, gut and skin, ILCs form a link between the innate and adaptive immunity. This review summarizes recent evidences on how skin and gastrointestinal mucosal immune system contribute to both homeostasis and the development of food allergy, as well as the involvement of ILCs towards inflammatory processes and regulatory mechanisms.

Peer review status:Published

18 Sep 2020Submitted to Allergy
21 Sep 2020Submission Checks Completed
21 Sep 2020Assigned to Editor
22 Sep 2020Reviewer(s) Assigned
28 Oct 2020Review(s) Completed, Editorial Evaluation Pending
29 Oct 2020Editorial Decision: Revise Minor
29 Jan 20211st Revision Received
01 Feb 2021Submission Checks Completed
01 Feb 2021Assigned to Editor
01 Feb 2021Reviewer(s) Assigned
02 Feb 2021Review(s) Completed, Editorial Evaluation Pending
04 Feb 2021Editorial Decision: Accept
Jul 2021Published in Allergy volume 76 issue 7 on pages 2002-2016. 10.1111/all.14776