Population
This study comprised consecutive patients treated at the Heart Institute
of Hospital das Clínicas, Faculdade de Medicina, Universidade de São
Paulo with inherited CChs (LQTS, BrS or CPVT) and ICD receiving optimal
drug therapy. The inclusion criteria were patients having dental caries,
unsatisfactory restorations in the mandible and restorative dental
treatment indication. The exclusion criteria were the following: allergy
to lidocaine, sodium metabisulfite, or methylparaben; patients with
recurrent syncope or sustained arrhythmias documented for at least 3
months, including appropriate and innappropriate ICD shocks; patients
who had received epinephrine in the previous 24 hours; and patients with
a body weight <20 kg (a child ≅ 6 years old because of the
maximum safe dose of lidocaine, 4.4 mg/kg, used in 2 anesthetic
cartridges 23).
All patients were included after reading and signing the written
informed consent form. This study was approved by the Ethics Committee
of Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de
São Paulo (18221913.5.0000.0068) and was previously registered at
ClinicalTrials.gov (ID: NCT03182777) and can be accessed at
https://clinicaltrials.gov/ct2/show/NCT03182777?term=NCT03182777&rank=1