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Physical fitness and quality of life in adolescents with asthma and fixed airflow obstruction
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  • Andrey Sousa,
  • Anna Lúcia Cabral,
  • Ronaldo Silva,
  • José Grindler,
  • Alfredo Fonseca,
  • Milton Martins,
  • Celso Carvalho
Andrey Sousa
University of São Paulo
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Anna Lúcia Cabral
Darcy Vargas Children’s Hospital
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Ronaldo Silva
Universidade Brasil
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José Grindler
School of Medicine, University of Sao Paulo
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Alfredo Fonseca
School of Medicine, University of Sao Paulo
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Milton Martins
School of Medicine, University of Sao Paulo
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Celso Carvalho
School of Medicine, University of Sao Paulo
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Abstract

Asthma is a disease characterized by reversible bronchoconstriction, but some subjects develop fixed airflow obstruction (FAO). Subjects with FAO present more asthma symptoms and may have increased sedentary behavior; however, the effect of FAO on aerobic fitness and physical activity levels (PAL) remains poorly understood. Aim: To compare adolescents with asthma and FAO and adolescents with asthma without FAO in terms of aerobic fitness, PAL, muscle strength, and health-related quality of life (HRQoL). Methods: This cross-sectional study included adolescents with asthma, both sexes, and aged 12 to 18 years. They were divided into 2 groups: FAO and non-FAO groups. The adolescents were diagnosed with asthma in accordance with the Global Initiative for Asthma guidelines and underwent optimal pharmacological treatment for at least 12 months. FAO was diagnosed when FEV1/FVC ratio was below the lower limit of normal range after optimal treatment. Aerobic fitness, PAL, peripheral and respiratory muscle strength, and HRQoL were evaluated. Results: No significant differences were observed between FAO and non-FAO groups regarding the peak oxygen uptake (34.6±8.5 vs. 36.0±8.4 mLO2/min/kg), sedentary time (578±126 vs. 563±90 min/day), upper limb muscle strength (29.1±5.9 vs. 28.1±5.7 kgf), lower limb muscle strength (42.8±8.6 vs. 47.6±9.6 kgf), or HRQoL (5.1±1.3 vs. 4.7±1.4 score) (p>0.05). However, the FAO group exhibited a higher maximal expiratory pressure than did the non-FAO group (111.5±15.5 vs. 101.5±15.0 cmH2O, respectively). Conclusion: Our results suggest that FAO does not impair aerobic fitness, PAL, peripheral muscle strength, or HRQoL in adolescents with asthma. Furthermore, adolescents with asthma were physically deconditioned.

Peer review status:IN REVISION

07 Jul 2020Submitted to Pediatric Pulmonology
07 Jul 2020Assigned to Editor
07 Jul 2020Submission Checks Completed
10 Jul 2020Reviewer(s) Assigned
31 Jul 2020Review(s) Completed, Editorial Evaluation Pending
02 Aug 2020Editorial Decision: Revise Major