Study Selection Criteria
To select only the relevant studies, the titles and abstracts of all citations identified by bibliographic research were examined. In this stage, all studies were included who investigated the specific theme: Effect of voltage-dependent sodium channel mutations and aspects related to cardiac muscle in children.
For characterization aspects of the included studies, the following criteria were adopted as the most important: presence of cardiac arrhythmia in children and genetic sodium channel polymorphism. Then, all the necessary data for the characterization were organized and shown in table form. The data that were not identified in the studies were filled in with NE (not evaluated).
RESULTS
Among the 2196 studies identified through a systematic literature review, thirty studies related to the theme were identified for complete review. Five duplicate articles were excluded, two were not in English, seventeen did not use children or adolescents aged 7 to 14 years in the research sample and two studies had not outcome of interest. Totaling four articles included and characterized in table 1. The main results of the studies included in this review are shown in Table 2.
Table 1 – Characteristics of the study and patients