Study Selection Criteria
To select only the relevant studies, the titles and abstracts of all
citations identified by bibliographic research were examined. In this
stage, all studies were included who investigated the specific theme:
Effect of voltage-dependent sodium channel mutations and aspects related
to cardiac muscle in children.
For characterization aspects of the included studies, the following
criteria were adopted as the most important: presence of cardiac
arrhythmia in children and genetic sodium channel polymorphism. Then,
all the necessary data for the characterization were organized and shown
in table form. The data that were not identified in the studies were
filled in with NE (not evaluated).
RESULTS
Among the 2196 studies identified through a systematic literature
review, thirty studies related to the theme were identified for complete
review. Five duplicate articles were excluded, two were not in English,
seventeen did not use children or adolescents aged 7 to 14 years in the
research sample and two studies had not outcome of interest. Totaling
four articles included and characterized in table 1. The main results of
the studies included in this review are shown in Table 2.
Table 1 – Characteristics of the study and patients