An Unexpected Cause of Headache and Splenic Lesions During anti-TNF
Therapy in Crohn's Disease
Abstract
Anti-tumor necrosis factor (TNF) agents have revolutionized the
treatment of several immune-mediated inflammatory diseases, including
Crohn’s disease and ulcerative colitis. Although greatly effective,
theses biologics put the patients at increased risk for developing
serious and opportunistic infections and some types of cancer as
lymphomas, the latter one especially when on combination of anti-TNF and
thiopurines. Here we report a male who developed an atypical
presentation of a severe opportunistic infection when using anti-TNF
agent for Crohn’s disease treatment.