Abstract: Coronavirus disease 2019 (COVID-19), has affected many regions and countries. It is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has a powerful ability to spread and is highly lethal. SARS-CoV-2 belongs to CoVs, together with the SARS-CoV and middle east respiratory syndrome-CoV. SARS-CoV-2 damages the lungs and some other organs in humans by infecting cells via binding to the ACE2 receptor. The infection with SARS-CoV-2 results in varying degrees of clinical manifestations. Although the amount of the evidence in favor of the impact of COVID-19 on the clinical manifestations of myocardial injury and the onset of cardiovascular disease (CVD) is increasing, myocardial cell damage caused by viruses not identified in biopsies and autopsies. Therefore, it has been suggested that viruses might affect cardiac function by mechanisms other than direct infection of cardiomyocytes, and several plausible conjectures have been proposed. Based on the fact that the viruses can exert influence on multiple systems in an organism, this article describes and proposes, for the first time, the possible impact of the interaction between the brain and the heart on the cardiovascular system in COVID-19 patients.