2.2 Takotsubo syndrome
Sympathetic hyperexcitability, coronary vasospasm, and microcirculation disorders were considered the most likely factors responsible for Takotsubo syndrome (TTS). Acute cardiac dysfunction caused by TTS and subarachnoid hemorrhage might share a similar mechanism, namely the release of a large amount of catecholamines, but the understanding of the precise pathological mechanism was currently limited [13]. Although very rare, TTS might become an effective differential diagnosis of myocardial injury in COVID-19 patients. Among the reported TTS cases, one patient was confirmed to suffer from a typical SARS-CoV-2-infected TTS. This finding suggested that the enormous emotional pressure and respiratory tract infection caused by the virus may be a cause of TTS [14].