Concluision
In summary, this study intervened the growth of CRSwNP tissues by glucocorticoids, analyzed the differential gene expression of transcriptomes from normal CRSwNP tissues, and initially predicted that the RPL26 gene played an important role in the process of edema of CRSwNP tissues. Then we established the RPL26 silencing and overexpressing CRSwNP cell system through CRISPR-Case9 gene editing technology, and studied the effect of RPL26 silencing and overexpression on CRSwNP tissue edema. It was initially verified that the high expression of RPL26 gene can reduce the degree of CRSwNP tissue edema, proving that RPL26 gene plays an important role in the regulation of CRSwNP tissue edema. However, the mechanism by which the rpl26 gene functions still needs further research and confirmation.