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EFFECT OF THE POVIDONE IODINE, HYPERTONIC ALKALINE SOLUTION AND SALINE NASAL LAVAGE ON NASOPHARYNGEAL VIRAL LOAD IN COVID-19
  • +13
  • Aysegul Karaaltin,
  • ozgur yigit,
  • dogan cakan,
  • özer akgül,
  • Enes Yiğit,
  • yetkin zeki yılmaz,
  • Kays Burak Çakır,
  • gamze çiftçi,
  • Nihal Seden,
  • abdurrahman çağlıyan,
  • Efe Can,
  • özgür dikme,
  • yalçın hacıoğlu,
  • ilker inanç balkan,
  • özgün enver,
  • Ahmet Ozdogan
Aysegul Karaaltin
Istanbul University

Corresponding Author:batioglu@yahoo.com

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ozgur yigit
istanbul education and research hospital
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dogan cakan
Istanbul University-Cerrahpasa
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özer akgül
Istanbul Aydin Universitesi
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Enes Yiğit
Istanbul Teaching and Research Hospital
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yetkin zeki yılmaz
İstanbul Üniversitesi-Cerrahpaşa
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Kays Burak Çakır
Istanbul Universitesi-Cerrahpasa
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gamze çiftçi
İstanbul Üniversitesi-Cerrahpaşa
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Nihal Seden
Istanbul Teaching and Research Hospital
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abdurrahman çağlıyan
Istanbul Teaching and Research Hospital
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Efe Can
Istanbul Teaching and Research Hospital
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özgür dikme
Istanbul Education Research Hospital
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yalçın hacıoğlu
Istanbul Teaching and Research Hospital
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ilker inanç balkan
İstanbul Üniversitesi-Cerrahpaşa
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özgün enver
Istanbul Aydin Universitesi
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Ahmet Ozdogan
Istanbul University Cerrahpasa Medical Faculty
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Abstract

Objective: The causative virus of COVID-19 is SARS-CoV-2. The aim of the present study was to invastigate the in vivo virucidal activity of nasal irrigation with saline, nasal irrigation with Povidone-iodine (PVP-I) 1%, nasal irrigation with hypertonic alkaline and nasal irrigation with PVP-I 1% against SARS CoV- 2. Design: The present study was a prospective randomized clinical trial. Setting: A multicenter study involving tertiary care centers. Participants: The study included adult outpatients whose qualitative SARS-CoV-2 RT-PCR tests in nasopharyngeal swabs were positive. One hundred twenty patients divided into four equal groups. Standard COVID-19 treatment was given to group 1 (n=30), nasal irrigation containing isotonic solution was added to patients’ treatment in group 2 (n=30), nasal irrigation containing 1% PVP solution was added to patients’ treatment in group 3(n=30), and nasal irrigation containing 1% PVP solution and nasal irrigation containing hypertonic alkaline solution was added to patients’ treatment in group 4 (n=30). Main outcome measures: On the first day of diagnosis (day 0), nasopharyngeal swab samples were taken, on the 3rd and 5th days the nasopharyngeal viral load reduction in quantitative RT-PCR tests were calculated. Results: Between the 0-3rd Day and 0-5th days, the nasopharyngeal viral load reduction was significant in all groups (p< .05). In paired comparisons of groups, the nasopharyngeal viral load decrease in group 4 in first 3 days was significantly lower than all groups (p < .05). The nasopharyngeal viral load degrease in groups 3 and 4 in the first 5 days were significantly lower than group 1 (p < .05). Conclussion: This study was reveal that the use of hypertonic alkaline nasal irrigation together with 1% povidone-iodine was more effective in reducing viral load in the early period. The decreased nasopharyngeal viral load may reduce the carriage of infectious SARS-CoV-2 in patients. Our results suggest that 1% povidone-iodine and hypertonic alkaline nasal irrigation may be promising modality to prevent the COVID-19 epidemic.
25 Sep 2022Submitted to Clinical Otolaryngology
26 Oct 2022Submission Checks Completed
26 Oct 2022Assigned to Editor
02 Nov 2022Reviewer(s) Assigned
21 Nov 2022Review(s) Completed, Editorial Evaluation Pending
27 Nov 2022Editorial Decision: Revise Major
31 Dec 20221st Revision Received
10 Jan 2023Submission Checks Completed
10 Jan 2023Assigned to Editor
15 Jan 2023Reviewer(s) Assigned