Associate with TMB and IDH mutation
We also analyzed the association between IDH1/IDH2 mutations and TMB in five type of cancer. As shown in Figure 2F . The TMB were significantly higher in lung cancer, colorectal cancer and gastric cancer than biliary tract cancer (p = 0.0164, p<0.0001, p = 0.0067, respectively). In addition, we also analyzed the relationship between IDH mutation/wild-type with TMB in biliary tract cancer in Figure 2G . Patients with IDHmutation had lower TMB compared with patients with wild-type IDH(p = 0.0236).