Study design and participants
The ANODE trial is a is a multi‐centre, double‐blind, randomised,
placebo‐controlled trial that was run between March 2013 and June
20181. The inclusion criteria, exclusion criteria and
ethics approval for the ANODE trial can be found in their
appendix1. This study is a cost-utility analysis based
on the primary data it reported and as such there was no patient or
public involvement. In addition, this study received no external
funding.