Study design and participants
The ANODE trial is a is a multi‐centre, double‐blind, randomised, placebo‐controlled trial that was run between March 2013 and June 20181. The inclusion criteria, exclusion criteria and ethics approval for the ANODE trial can be found in their appendix1. This study is a cost-utility analysis based on the primary data it reported and as such there was no patient or public involvement. In addition, this study received no external funding.