Background: By interrupting all human-to-human transmission, SARS and MERS were effectively eradicated few years ago, but, due to the numerous asymptomatic cases of COVID-19, spreading of disease is facilitated and it will be difficult to overcome it in this way. Methodology: The aim of our study was to compare the efficacy and consequences of proposed epidemiological measures between countries. We analyzed the available databases to compare states with strict whit those with relatively liberal approach to COVID-19 prevention. Results: We showed a statistically significant difference in the number of patients and deaths caused by SARS-CoV-2 depending on the degree and timing of the epidemiological measures introduced in studied countries. Conclusion: Apart from the characteristics of the virus itself, the epidemiological measures that have been introduced, as well as their timing, are essential for preventing the spread of COVID 19 infection. In the absence of an effective drug or vaccine traditional epidemiological measures are the only weapon in the battle against COVID-19.