HCoV-229E
|
1965
URTI, common cold
|
APN (CD13)
|
Renal and GI epithelia, synaptic membranes, pericytes, myeloid cells,
fibroblast like cells. neurons
|
TMPRSS2
TMPRSS11D
|
(1,2,4)
|
HCoV-OC43
|
1967
URTI, common cold
|
9-O-acetylated sialic acid
|
Human epithelial cells, neurons
|
IFIT2/IFIT3
HLA-1
|
(4–6)
|
SARS-CoV
|
2002
Severe acute respiratory syndrome (SARS)
|
ACE2
|
Respiratory, intestinal epithelial cells, endothelial cells, renal
tubules, cerebral neurons, alveolar macrophages, DCs
|
cathepsin L, TMPRSS2/11D
DC-SIGN (CD206), DC-SIGNR
|
(7,8)
|
HCoV-NL63
|
2004
Bronchitis URI, common cold
|
ACE-2
|
Pneumocytes, intestinal epithelial cells, endothelial cells, renal
tubules, cerebral neurons, alveolar macrophages, DCs
|
heparan sulphate proteoglycans
|
(9)
|
HCoV-HKU1
|
2005
Pneumonia Common in children
|
9-O-acetylated sialic acid
|
human alveolar type II cells
|
HLA-C
|
(10)
|
MERS-CoV
|
2012
SARS
|
DPP4 (CD26)
|
Intestinal, alveolar, renal, hepatic and prostate cells activated
leukocytes
|
furin
|
(11)
|
SARS-CoV-2
|
2019
SARS, Severe disease associated with ageing and comorbidities
|
ACE2
|
Respiratory, intestinal epithelial cells, endothelial cells, renal
tubules, cerebral neurons, alveolar macrophages, DCs
|
furin
TMPRSS2
|
(3)
|