Gene enrichment analysis
In order to find out why the risk score can predict the survival of patients with COAD, the samples were grouped according to the median risk score, namely high-risk group and low-risk group. Implement GSEA in the high-risk and low-risk groups to investigate the ways of change. We identified the KEGG enrichment pathway of model genes in TCGA-COAD. GSEA analysis showed that the altered genes were observed to be enriched in several common pathways. Among the 178 genomes of the high-risk phenotype group, 130 genomes were up-regulated, and 62 genomes were significant at FDR <25%. Most enrichment pathways are concentrated in metabolic pathways, such as arginine and proline metabolism, fructose and mannose metabolism, galactose metabolism, and nicotinate and nicotinamide metabolism. The results also include some well-known cancer-related pathways, such as antigen processing and presentation, basic transcription factors, endometrial cancer, glycolytic gluconeogenesis, erbb signaling pathway, and glycosylphosphatidylinositol gpi anchor biosynthesis. It shows some representative pathways in figure 4. The relevant parameters of the channel are listed in Table 2. The results further illustrate the role of metabolic mechanisms in COAD.