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Role of Dietary Fiber in Promoting Immune Health -- An EAACI Position Paper
  • +19
  • Carina Venter,
  • Rosan Meyer,
  • Matthew Greenhawt,
  • Isabella Pali-Schöll,
  • Bright Nwaru,
  • Caroline Roduit,
  • Eva Untersmayr,
  • K Adel-Patient,
  • Ioana Agache,
  • Carlo Agostoni,
  • Cezmi Akdis,
  • Mary Feeney,
  • Karin Hoffmann-Sommergruber,
  • Nonhlanhla Lunjani,
  • Kate Grimshaw,
  • Imke Reese,
  • Pete Smith,
  • Milena Sokolowska,
  • Emilia Vassilopoulou,
  • Berber Vlieg - Boerstra,
  • Jens Walter,
  • Liam O'Mahony
Carina Venter
Section of Allergy and Immunology University of Colorado School of Medicine
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Rosan Meyer
Imperial College London
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Matthew Greenhawt
Section of Allergy and Immunology University of Colorado School of Medicine
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Isabella Pali-Schöll
Comparative Medicine Messerli Research Institute of the University of Veterinary Medicine Vienna Medical University Vienna Vienna Austria
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Bright Nwaru
Goteborgs universitet Institutionen for medicin
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Caroline Roduit
UniversitatsSpital Zurich
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Eva Untersmayr
Medizinische Universitat Wien Zentrum fur Pathophysiologie Infektiologie und Immunologie
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K Adel-Patient
Université Paris-Saclay CEA INRAE UMR MTS/SPI/Laboratoire d'Immuno-Allergie Alimentaire (LIAA) INRA CEA Université Paris Saclay Gif sur Yvette Cedex France
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Ioana Agache
Transylvania University Brasov Romania
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Carlo Agostoni
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
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Cezmi Akdis
Christine Kühne-Center for Allergy Research and Education Davos Switzerland
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Mary Feeney
King's College London Division of Asthma Allergy and Lung Biology
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Karin Hoffmann-Sommergruber
Medizinische Universitat Wien Zentrum fur Pathophysiologie Infektiologie und Immunologie
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Nonhlanhla Lunjani
University College Cork APC Microbiome Institute
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Kate Grimshaw
Salford Royal NHS Foundation Trust
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Imke Reese
Private Practice for Dietary Advice and Nutrition Therapy Munich Germany
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Pete Smith
Griffith University School of Medicine and Dentistry
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Milena Sokolowska
Swiss Institute of Allergy and Asthma Research (SIAF) University of Zurich Davos Switzerland
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Emilia Vassilopoulou
Department of Nutritonal Sciences and Dietetics International Hellenic University Thessaloniki Greece
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Berber Vlieg - Boerstra
OLVG Department of Paediatrics Amsterdam The Netherlands
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Jens Walter
University College Cork APC Microbiome Institute
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Liam O'Mahony
University College Cork APC Microbiome Institute
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Abstract

Microbial metabolism of specific dietary components, such as fiber, contribute to the sophisticated inter-kingdom dialogue in the gut that maintains a stable environment with important beneficial physiological, metabolic, and immunological effects on the host. Historical changes in fiber intake may be contributing to the increase of allergic and hypersensitivity disorders as fiber-derived metabolites are evolutionarily hardwired into the molecular circuitry governing immune cell decision making processes. In this review, we highlight the importance of fiber as a dietary ingredient, its effects on the microbiome, its effects on immune regulation, and potential mechanisms for dietary fibers in the prevention and management of allergic diseases. In addition, we review the human studies examining fiber or prebiotic interventions on asthma and respiratory outcomes, allergic rhinitis, atopic dermatitis, and overall risk of atopic disorders. While exposures, interventions and outcomes were too heterogeneous for meta-analysis, there is significant potential for using fiber in targeted manipulations of the gut microbiome and its metabolic functions in promoting immune health.
19 Nov 2021Submitted to Allergy
23 Nov 2021Submission Checks Completed
23 Nov 2021Assigned to Editor
28 Nov 2021Reviewer(s) Assigned
29 Dec 2021Review(s) Completed, Editorial Evaluation Pending
04 Jan 2022Editorial Decision: Revise Minor
19 Apr 20221st Revision Received
20 Apr 2022Submission Checks Completed
20 Apr 2022Assigned to Editor
20 Apr 2022Reviewer(s) Assigned
03 May 2022Review(s) Completed, Editorial Evaluation Pending
07 May 2022Editorial Decision: Revise Minor