Associations of phthalate concentrations with serum periostin level, YKL-40 level, and lung function
Analysis of the relationships of urinary phthalate metabolites with serum periostin level and serum YKL-40 level indicated significant associations in the quartiles of urinary Σ4HMWP and Σ3LMWP metabolites with periostin (Table 3). After adjustment using a generalized linear regression model with the logit function, these relationships remained significant. After adjustment, the level of urinary Σ4HMWP metabolites was also significantly associated with YKL-40 (adjusted β: 0.882, 95% CI: 0.687 to 0.983; P =.032), but level of urinary Σ3LMWP metabolites was not significantly associated with YKL-40 level.
Analysis of the relationships of serum periostin and serum YKL-40 levels with pulmonary function indicated periostin level was significantly associated with Rrs5 (adjusted β: 0.048, 95% CI: 0.015 to 0.081;P = .005), but not with FeNO (Table 4). There was also a significant association between periostin level and Rrs5-20 (adjusted β: 0.040, 95% CI: 0.011 to 0.069; P = .007). The serum YKL-40 level was not significantly associated with Rrs5 or Rrs5-20.