Associations of phthalate concentrations with serum periostin
level, YKL-40 level, and lung function
Analysis of the relationships of urinary phthalate metabolites with
serum periostin level and serum YKL-40 level indicated significant
associations in the quartiles of urinary Σ4HMWP and
Σ3LMWP metabolites with periostin (Table 3). After
adjustment using a generalized linear regression model with the logit
function, these relationships remained significant. After adjustment,
the level of urinary Σ4HMWP metabolites was also
significantly associated with YKL-40 (adjusted β: 0.882, 95% CI: 0.687
to 0.983; P =.032), but level of urinary Σ3LMWP
metabolites was not significantly associated with YKL-40 level.
Analysis of the relationships of serum periostin and serum YKL-40 levels
with pulmonary function indicated periostin level was significantly
associated with Rrs5 (adjusted β: 0.048, 95% CI: 0.015 to 0.081;P = .005), but not with FeNO (Table 4). There was also a
significant association between periostin level and Rrs5-20 (adjusted β:
0.040, 95% CI: 0.011 to 0.069; P = .007). The serum YKL-40 level
was not significantly associated with Rrs5 or Rrs5-20.