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Refractory malignant hepatocellular tumor consisting of hepatocellular carcinoma and hepatoblastoma in a 10-year-old male
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  • Minako Sugiyama,
  • Shinsuke Hirabayashi,
  • Yukayo Terashita,
  • Yuko Cho,
  • Akihiro Iguchi,
  • Yoshihito Ohhara,
  • Daisuke Abo,
  • Shohei Honda,
  • Emi Takakuwa,
  • Atsushi Manabe
Minako Sugiyama
Hokkaido University Graduate School of Medicine
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Shinsuke Hirabayashi
Hokkaido University Graduate School of Medicine
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Yukayo Terashita
Hokkaido University Graduate School of Medicine School of Medicine
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Yuko Cho
Hokkaido University Graduate School of Medicine
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Akihiro Iguchi
Hokkaido University Graduate School of Medicine
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Yoshihito Ohhara
Faculty of Medicine and Graduate School of Medicine, Hokkaido University
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Daisuke Abo
Hokkaido University Graduate School of Medicine
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Shohei Honda
Hokkaido University Graduate School of Medicine
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Emi Takakuwa
Hokkaido University Hospital
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Atsushi Manabe
Hokkaido University Graduate School of Medicine
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Abstract

Although hepatoblastoma constitutes most of hapetic tumours in chidren, other types of tumors are often observed in older patients. We report a case of a 10-year-old Japanese boy with a transitional hepatic tumour consisting of both hepatoblastoma and hepatocellular carcinoma. After surgery and chemotherapy with cisplatin and pirarubicin, the tumour regressed, however, new tumours in the liver evolved with element of hepatocellular carcinoma. He died as a result of hepatic failure afte lenvatinib and drug-eluting transcatheter arterial chemoembolisation 18 months after diagnosis. Examinations of a panel of genomic alterations did not identify any therapeutic targets.