Results
1 month after the LAAO procedure compared to baseline value, we found Ks improved by 39.3% measured in clots prepared from peripheral blood (p=0.019) and also after adjustment for fibrinogen (p=0.027). Higher Ks was associated with improved clot susceptibility to lysis (r=-0.67, p=0.013). We found shortened CLT by 10.3% (p=0.0020); a 52% lower PAI-1 antigen levels (p=0.023) along with 8.9% increased plasminogen activity (p=0.0077). A tendency to decreased thrombin generation, reflected by decreased ETP and peak thrombin generated, was observed 1 month after the LAAO procedure (p=0.072 and p=0.087). No differences were found in tPA and TAFI plasma levels (both p>0.05).