Dose (mg) |
4 (3-5) |
2 (1-3) |
0.016 |
Weight (kg) |
54 (51.3-78.0) |
65 (43-82) |
0.690 |
Dose/Weight (mg/kg) |
0.077 (0.045-0.097) |
0.037 (0.016-0.047) |
0.032 |
AUC in Tac BID (ng·hr/mL) |
126.3 (98.2-146.9) |
107.0 (102.4-126.7) |
0.310 |
AUC in Tac QD (ng·hr/mL) |
112.5 (81.0-168.6) |
96.1 (68.5-131.7) |
0.310 |
Cmin in Tac BID (mg/mL) |
3.77 (3.05-4.20) |
3.07 (2.76-4.47) |
0.421 |
Cmin in Tac QD (mg/mL) |
3.04 (1.85-4.21) |
2.59 (1.81-4.47) |
0.690 |
Cmax in Tac BID (mg/mL) |
8.20 (4.94-11.54) |
9.93 (5.08-10.48) |
0.690 |
Cmax in Tac QD (mg/mL) |
9.52 (6.81-11.90) |
7.85 (3.54-10.86) |
0.151 |
Dose-adjusted Cmin in Tac BID (ng/mL/mg) |
0.918 (0.754-1.050) |
1.535
(0920-3.400) |
0.056 |
Dose-adjusted Cmin in Tac QD (ng/mL/mg) |
0.680 (0.608-1.053) |
1.295
(0.603-2.235) |
0.151 |
Dose-adjusted Cmax in Tac BID (ng/mL/mg) |
1.65 (1.58-2.40) |
3.79
(3.31-5.16) |
0.008 |
Dose-adjusted Cmax in Tac QD (ng/mL/mg) |
2.73 (1.36-3.10) |
3.54
(1.85-5.43) |
0.310 |
Dose-adjusted AUC in Tac BID (ng·hr/mL/mg) |
29.4 (25.3-33.0) |
53.5
(35.2-102.4) |
0.008 |
Dose-adjusted AUC in Tac QD (ng·hr/mL/mg) |
27.0 (21.0-42.2) |
48.0
(24.2-68.5) |
0.095 |
Dose/kg-adjusted Cmin Tac BID (ng/mL/mg/kg) |
0.015 (0.013-0.018) |
0.021 (0.012-0.053) |
0.548 |
Dose/kg-adjusted Cmin Tac QD (ng/mL/mg/kg) |
0.013 (0.009-0.014) |
0.017
(0.009-0.052) |
0.222 |
Dose/kg-adjusted Cmax Tac BID (ng/mL/mg/kg) |
0.032 (0.020-0.046) |
0.069 (0.040-0.088) |
0.032 |
Dose/kg-adjusted Cmax Tac QD (ng/mL/mg/kg) |
0.038 (0.025-0.052) |
0.053
(0.029-0.126) |
0.421 |
Dose/kg-adjusted AUC Tac BID (ng·hr/mL/mg/kg) |
0.492 (0.423-0.553) |
0.716 (0.455-1.600) |
0.151 |
Dose/kg-adjusted AUC Tac QD (ng·hr/mL/mg/kg) |
0.458 (0.390-0.541) |
0.643 (0.379-1.532) |
0.421 |