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The short-term, genome-wide effects of indirect selection deserve study: a response to Charlesworth and Jensen (2022)
  • Zachariah Gompert,
  • Jeff Feder,
  • Patrik Nosil
Zachariah Gompert
Utah State University

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Jeff Feder
U. Notre Dame
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Patrik Nosil
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We recently published a paper quantifying the genome-wide consequences of natural selection, including the effects of indirect selection due to the correlation of genetic regions (neutral or selected) with directly selected regions (Gompert et al. 2022). In their critique of our paper, Charlesworth & Jensen (2022) make two main points: (i) indirect selection is equivalent to hitchhiking and thus well documented (i.e., our results are not novel), and (ii) that we do not demonstrate the source of linkage disequilibrium (LD) between SNPs and the Mel-Stripe locus in the Timema cristinae experiment we analyze. As we discuss in detail below, neither of these are substantial criticisms of our work.
01 Feb 2022Submitted to Molecular Ecology
01 Feb 2022Submission Checks Completed
01 Feb 2022Assigned to Editor
02 Feb 2022Reviewer(s) Assigned
15 Mar 2022Review(s) Completed, Editorial Evaluation Pending
27 May 2022Editorial Decision: Revise Minor
21 Jun 2022Review(s) Completed, Editorial Evaluation Pending
21 Jun 20221st Revision Received
01 Jul 2022Editorial Decision: Accept
31 Jul 2022Published in Molecular Ecology. 10.1111/mec.16614