Peanut allergic (n=20)* Median (IQR) Peanut sensitised but not allergic (n=28)* Median (IQR)
P value
Peanut extract SPT mm 3 months** 12 months 36 months 7-11 year 0 (0, 0) (n=5) 4.5 (3, 7.5) (n=18) 8.5 (6.3, 10.3) 9.3 (7.3, 10.3) 0 (0, 2) (n=11) 1 (0, 4.8) 1.5 (0, 5) 0 (0, 2) 0.20 0.02 <0.001 <0.001
Peanut sIgE kUA/L 3 months 12 months 36 months 7-11 years 0.05 (0.03, 0.2) (n=18) 1.4 (0.64, 6.5) (n=16) 9.3 (1.6, 46.7) (n=19) 24.8 (3.6, 85.2) 0.06 (0.03, 0.2) (n=25) 1.5 (1.1, 5.4) (n=27) 0.8 (0.2, 1.5) 0.9 (0.1, 5.2) (n=27) 0.8 0.7 <0.001 <0.001
Peanut components-sIgE kUA/L (3 months) Ara h 1 Ara h 2 Ara h 3 Ara h 8 (n=18) 0.07 (0, 0.4) 0.01 (0.01, 2.0) 0.02 (0.002, 0.04) 0.003 (0.002, 0.005) (n=25) 0.1 (0, 0.2) 0.005 (0.002, 0.01) 0.01 (0.005, 0.02) 0.003 (0.001, 0.005) 1.00 0.11 0.67 0.73
Peanut components-sIgE kUA/L (12 months) Ara h 1 Ara h 2 Ara h 3 Ara h 8 (n=16) 0.4 (0.05, 4.0) 0.6 (0.07, 6.7) 0.06 (0.02, 0.3) 1.5 (0.03, 10.3) (n=27) 0.2 (0.02, 0.7) 0.2 (0.02, 1.2) 0.1 (0.03, 0.5) 0.004 (0.001, 0.013) 0.81 0.39 0.49 0.24
Peanut components-sIgE kUA/L (36 months) Ara h 1 Ara h 2 Ara h 3 Ara h 8 (n=19) 0.1 (0.04, 1.8) 4.0 (1.3, 28.3) 0.03 (0.02, 0.4) 1.5 (0.03, 10.3) 0.1 (0.03, 0.2) 0.04 (0.02, 0.2) 0.1 (0.06, 0.2) 0.04 (0.01, 0.5) 0.38 <0.001 0.72 0.14
Peanut components-sIgE kUA/L (7-11 years) Ara h 1 Ara h 2 Ara h 3 Ara h 6 Ara h 8 1.8 (0.12, 28.4) 16.3 (1.9, 54.5) 0.28 (0.02, 3.5) 10.4 (1.6, 31.9) 1.5 (0.03, 10.3) (n=27) 0.06 (0.01, 0.2) 0.06 (0.03, 0.2) 0.06 (0.03, 0.2) 0.06 (0.03, 0.1) 0.26 (0.06, 0.6) <0.001 <0.001 <0.01 <0.001 0.14
Peanut sIgG4 g/L 3 months 12 months 36 months 7-11 years 11.3 (0, 40.1) (n=17) 202.8 (74.6, 433.6) (n=16) 407.4 (175.7,1526.3) (n=18) 736.2 (210.9,1482.4) 7.3 (0, 27.3) (n=22) 78.3 (34.2, 506.9) (n=26) 353.4 (96.4, 1882.8) 523.7 (124.5,2673.3) (n=27) 0.54 0.69 0.51 0.88
Peanut sIgG4:sIgE ratios 3 months 12 months 36 months 7-11years 9.2 (0, 211.1) (n=17) 35.9 (7.1, 166.8) (n=16) 19 (8.6, 51.2) (n=12) 11.3 (5.1, 35.1) 15 (0, 326.2) (n=22) 15.1 (4.7, 296.4) (n=26) 191.4 (39.6, 2493.6) (n=19) 544 (30.4, 2448) (n=27) 0.95 0.70 <0.01 <0.001
MAT to peanut (%CD63 LAD2 cells) 3 months 12 months 36 months 7-11 years 10.7% (8.7-12.7) (n=2) 0.7% (-0.34, 11.6) (n=15) 11.5% (1.3, 30.2) 12.2% (5.0, 35.8) – 0.32% (-0.1, 7.8) (n=25) 0.19% (-0.2, 0.6) (n=26) 0.3% (0.1, 0.8) (n=27) – 0.31 p<0.001 p<0.001
*The number of patients in the groups differ based on sample availability and are denoted separately. **At the 3m time point, only children in the early introduction group had SPT performed and very few had sufficient bloods for MAT to be performed. *The number of patients in the groups differ based on sample availability and are denoted separately. **At the 3m time point, only children in the early introduction group had SPT performed and very few had sufficient bloods for MAT to be performed. *The number of patients in the groups differ based on sample availability and are denoted separately. **At the 3m time point, only children in the early introduction group had SPT performed and very few had sufficient bloods for MAT to be performed. *The number of patients in the groups differ based on sample availability and are denoted separately. **At the 3m time point, only children in the early introduction group had SPT performed and very few had sufficient bloods for MAT to be performed.