3.4 Detection of microorganism contamination
In one sample (iw052), only 90.5% reads could be aligned to the human
reference genome, which was much lower than other samples
(>98%) (Figure S1a ). A review of unaligned reads
revealed that 99.3% of them were enterobacterial in origin
(Figure S1b ), suggesting sample contamination or infection. We
recollected the blood two months later and no enterobacteria were
detected in the sequencing data.