ACKNOWLEDGEMENTS
We would like to thank the patients and their family members for participating in the study. The sequencing kits were supplied by Illumina. The genome sequencing was performed by Berry Genomics. The data were stored and analyzed in a cloud service GeneDock.
This work was funded by the Precision Medical Research of National Key Research and Development Program (2018YFC1002200, 2019YFC1005100 to Y. Yu, 2018YFC1002400 to K. Sun), National Natural Science Foundation of China (81873724 to Y. Sun, and 82070914 and 81873671 to Y. Yu), Shanghai Shen Kang Hospital Development Center (SHDC12017109 to Y. Yu), the Shanghai Science and Technology Commission (19140904500 to Y. Yu), Jiaotong University Cross Biomedical Engineering (YG2017MS72 to Y. Yu), and Foundation of Shanghai Municipal Health Commission (shslczdzk05702, to Y. Yu and Y. Sun), and Municipal Education Commission-Gaofeng Clinical Medicine Grant Support (20191908, to Y. Yu).