Participants
From January 2017to October 2019,160 patientswho diagnosed otomycosis from out-patient department were selected as subjects.Written consent was obtained from each patient before including him in the study. Local ethics committee had approved the study.Inclusion criteria:(1) Diagnosed with otomycosis: visualization compatible with fungal debris is done through microscopic examination;(2)Cooperate with the doctor’s treatment and follow up on time. Exclusion criteria:(1)Pregnant and lactating women, patients who used other therapies or treatment, diseases or structural anomalies impeding therapeutic response evaluation;(2)Malignant invasive (acute or chronic) otitis externa complicated by mastoiditis or meningitis, or both.