Introduction
Chronic
spontaneous
urticaria (CSU) is a multifactorial mast cell-dependent inflammatory
disease, which is characterized by recurrent itchy wheals and/or
angioedema.
Several
immunological events have been described in CSU, which are
including inflammatory response and
platelet activation1-4.
It is known, that CRP is produced during an inflammatory reaction and is
elevated in various disorders including infections, cancer, autoimmune,
cardiovascular and gastrointestinal
diseases5-7.Recently, hypersensitive C-reactive
protein (hsCRP) has been shown to be helpful for potential adjunct for
global
risk
assessment
in the primary prevention of cardiovascular
disease8.
Moreover,recent findings demonstrated that
basophils
may play important roles in a variety of
inflammatory skin
diseases9.On the other hand,the platelet parameters
play an impotant and active role in the immune-inflammatory
response10,11. Mean
platelet volume (MPV) is an indicator of platelet size,which has been
shown to be the markers of platelet function and
activation10.
In addition,some studies have reported that the evaluation of disease
severity in patients with chronic spontaneous urticaria (CSU) is
essential for the adequate treatment of patients, and higher MPV was
associated with low-grade inflammatory conditions and a variety of risk
factors of cardiovascular
disorders10,12.The
correlation between biomarkers may be important in understanding of
pathogenetic processes in CSU and increasing prognostic
value2, yet the
prospective studies focusing on these relationship are still lacking.
Taken together, we sought to see whether there was any correlation
between the markers of inflammatory process and platelet activation in
CSU. Therefore, we measured circulating concentrations of hsCRP,
basophil count and MPV of CSU patients and the healthy subjects, and
then analyzed the relationship between markers and the disease severity
and the correlation between markers.
Patients andMethods