Introduction
Chronic spontaneous urticaria (CSU) is a multifactorial mast cell-dependent inflammatory disease, which is characterized by recurrent itchy wheals and/or angioedema. Several immunological events have been described in CSU, which are including inflammatory response and platelet activation1-4.
It is known, that CRP is produced during an inflammatory reaction and is elevated in various disorders including infections, cancer, autoimmune, cardiovascular and gastrointestinal diseases5-7.Recently, hypersensitive C-reactive protein (hsCRP) has been shown to be helpful for potential adjunct for global risk assessment in the primary prevention of cardiovascular disease8. Moreover,recent findings demonstrated that basophils may play important roles in a variety of inflammatory skin diseases9.On the other hand,the platelet parameters play an impotant and active role in the immune-inflammatory response10,11. Mean platelet volume (MPV) is an indicator of platelet size,which has been shown to be the markers of platelet function and activation10.
In addition,some studies have reported that the evaluation of disease severity in patients with chronic spontaneous urticaria (CSU) is essential for the adequate treatment of patients, and higher MPV was associated with low-grade inflammatory conditions and a variety of risk factors of cardiovascular disorders10,12.The correlation between biomarkers may be important in understanding of pathogenetic processes in CSU and increasing prognostic value2, yet the prospective studies focusing on these relationship are still lacking.
Taken together, we sought to see whether there was any correlation between the markers of inflammatory process and platelet activation in CSU. Therefore, we measured circulating concentrations of hsCRP, basophil count and MPV of CSU patients and the healthy subjects, and then analyzed the relationship between markers and the disease severity and the correlation between markers.
Patients andMethods