Viral Load Area Under the Curve (AUC):
The viral load AUC is calculated as the area under the viral load,V , time curve (copies/mL*day). This metric summarizes the total exposure to SARS-CoV-2 virions. This endpoint may have prognostic correlation to clinical outcome, however because it is highly dependent on the pre-intervention viral load values it is, consequently, insensitive to treatment interventions that occur beyond the peak viral load time. Moreover, because pre-intervention loads are seldom measured experimentally, it remains a theoretical phase, that provides important insights into pre (PrEP) and post exposure prophylaxis (PEP) strategies.