Viral cell cycle Example regimens Comment
p, Virion [Release] Remdesivir alone [Beigle et al., 2020] RCT of intravenous remdesivir in adults hospitalized with evidence of lower respiratory tract involvement, showed improved median recovery time of 11 vs 15 days.
c Virion [Kill] Antibodies, convalescent plasma, vaccines Under investigation
δ, Productive Cell [Death] p, Virion [Release] Interferon-b-1b, ribavirin [Hung et al., 2020] Protease inhibitors
Open label, prospective, randomized early treatment study (median 5 days, [IQR 3-7 days] since symptom onset) showed triple combination reduced viral shedding by 5 days sooner versus Lop/r alone
β, Target Cell [Infection] δ, Productive Cell [Death] p, Virion [Release] Hydroxychloroquine Azithromycin
Small case series with multiple issues with trial design and no comparator group limit inferences on virologic or clinical efficacy (Guatret et al., 2020). Concerns on QT prolongation (Mercuro et al., 2020)
Remdesivir + Hydroxycloroquine + lopinavir/ritonavir and/or interferon Potential RDV triple or quad combination antiviral regimen that covers three parts of viral cell cycle