Author contributions:
AC conducted the majority of the experiments and analyzed the data. BD
and SK conducted in silico studies. PM, designed the study and
supervised the project. PM and AC, wrote the manuscript with support
from BD ,SK and BM. PM is the guarantor of this work and, as such, has
full access to all the data in the study and takes responsibility for
the integrity of the data and the accuracy of the data analysis
Competing INTERESTS: authors declare no competing financial
interest”