Tmem251 knockdown does not affect apoptosis or chondrocyte proliferation
Tmem251 knockdown did not affect chondrocyte apoptosis 48hrs post-transfection (Figure 4H), indicating that increased apoptosis of chondrocytes may not be a major pathogenic mechanism in this condition. Moreover, chondrocyte proliferation was not significantly affected byTmem251 knockdown (Figure 4I). In summary, the Tmem251knockdown experiment demonstrated that TMEM251 is important for chondrocytic differentiation.