Process analysis and optimization of an EMR system used for producing
oligodextran are critical to improving EMR operating stability and cost
effectiveness. We developed a mathematical model to evaluate the effects
of operating conditions and membrane properties on the
reaction-separation behavior of an EMR. Our analysis shows that
tailoring a membrane with large porosity and uniform pore size
distribution can simultaneously improve product quality and production
efficiency. The optimum parameters of operating pressure and agitation
speed depend on the selection of operating mode. A higher operating
pressure was preferable for increasing the production efficiency of the
EMR system under a water feeding mode. However, since the membrane
suffered more severe fouling under a substrate feeding mode, extensive
agitation was required to inhibit membrane fouling and enhance
production yield. Our work paves the way for a new approach towards
design of highly effective and low-consumptive EMR systems for
oligodextran productio