Author (year)
Country
Study design
Study setting
Sample (Participant no. (Interventional, Control) Patient characteristics (age, gender)) Sample (Participant no. (Interventional, Control) Patient characteristics (age, gender))
Purpose of study
Outcome variables
n=sample size
I:C
Sirey et al. (2017)19 USA Quantitative (Randomized clinical effectiveness trial) Outpatient 231 (115, 116) The purpose to test the effectiveness of TIP to improve early adherence among older patients whose primary care physician newly initiated an antidepressant for depression. Medication adherence and depression severity
Alekhya et al. (2015)21 India Quantitative (Cross sectional study) Outpatient 103 Study the treatment and disease factors that influence compliance to the treatment of depression. Medication adherence; and disease and treatment factors
Abegaz et al. (2017)22 Ethiopia Quantitative (Prospective cross-sectional study) Inpatient and outpatient 270 The purpose to determine the degree of adverse drug reactions of antidepressants and their impact on the level of adherence and clinical outcome. Adverse drug reactions, medication adherence, and clinical outcomes (depression)
Al-Jumah et al. (2014)23 Saudi Arabia Quantitative (Non-experimental cross-sectional design) Outpatient 403 The purpose to explore patients’ adherence to antidepressant medication, and the factors associated with adherence among patients with depression. Medication adherence and beliefs about medication
Ho et al. (2017)24 Malaysia Qualitative (Grounded theory methodology) Outpatient 30 The purpose to explore the barriers and facilitators of patients’ adherence to antidepressants among outpatients with MDD. Barriers and facilitators of medication adherence
Yau et al. (2014)25 China Quantitative (Retrospective cohort study) Outpatient 189 The purpose to investigate the rate of noncontinuous antidepressant use, subsequent rate of relapse and recurrence in psychiatric Chinese outpatients, and factors associated with noncontinuous antidepressant use. noncontinuous antidepressant use, factors associated with noncontinuous antidepressant, and subsequent depression relapse and recurrence
Mert et al. (2015)34 Turkey Quantitative (Cross-sectional study) Inpatient 203 (n=39 patients with depression) The purpose to evaluate factors resulting in medication nonadherence before admission to the psychiatric service for patients with psychiatric disorder. Socio-demographic and clinical variables, medication adherence, and reasons of medication nonadherence
Al-Jumah et al. (2014)46 Saudi Arabia Quantitative (Non-experimental, observational design) Outpatient 403 The purpose to investigate the relationship between patient treatment satisfaction and adherence to antidepressants, and the role of patient beliefs toward medication in patient treatment satisfaction. Medication adherence, treatment satisfaction, and beliefs about medication
Aljumah and Hassali (2015)47 Saudi Arabia Quantitative (Prospective randomized controlled study) Outpatient 239 (119, 120) The purpose to assess whether pharmacist interventions based on SDM improved adherence and patient-related outcomes. Medication adherence, beliefs about medication, clinical outcomes (depression symptoms), patient involvement in decision-making, quality of life, and treatment satisfaction
Baeza-Velasco et al. (2019)48 France Quantitative (Cross-sectional study) Inpatient and outpatient 360 The purpose to explore medication adherence in patients with a major depression episode, and to identify sociodemographic, clinical, and psychosocial factors related to adherence status. Medication adherence, clinical and psychosocial factors (depressive symptoms, psychiatric antecedents, comorbidities, medication, pain, medication side effects, negative life events, childhood trauma, and attitudes to medication)
Bhat et al. (2018)49 USA Quantitative (Observational retrospective cohort study) Outpatient 258 The purpose to evaluate the feasibility of implementing a clinical pharmacist led multidisciplinary antidepressant telemonitoring service, evaluate potential opportunities for clinical pharmacy intervention, and identify which patients with major depressive disorder would be most likely to benefit from this service in primary care. Medication adherence, adverse effects, suicidal ideations, depressive symptoms, and pharmacist interventions.
Burnett-Zeigler et al. (2014)50 USA Quantitative (Prospective, observational study) Outpatient 186 The purpose to examine the associations between treatment attitudes and beliefs with race–gender differences in antidepressant adherence. Medication adherence, demographic variables, illness variables (past antidepressant use, number of prescribed medications, physical health status, mental health status, comorbid anxiety, somatic anxiety, and depression), activities of daily living and executive function, attitudes and beliefs toward depression treatment, and stigma
Chatterjee et al. (2017)51 India Quantitative (Ex-post facto design (criterion-group design)) Outpatient 60 The purpose to explore belief about the medication influences adherence to medication, and influence severity of depression and quality of life of patients with MDD residing at urban and rural areas. Medication adherence, beliefs about medication, depressive symptoms, and quality of life
De las Cuevas et al. (2014)52 Spain Quantitative (Cross-sectional study) Outpatient 145 The purpose to identify potential factors influencing adherence to antidepressant treatment by patients with mood disorders in the community mental health care setting. Socio-demographic characteristics and clinical variables, medication adherence, attitudes toward treatment, beliefs about medication, attitude toward concordance, depressive symptoms, and side effect
De Las Cuevas et al. (2014)53 Spain Quantitative (Cross-sectional study) Outpatient 119 The purpose to examine the relationship of psychological reactance, health locus of control and the sense of self-efficacy on adherence to treatment regimen among psychiatric outpatients with depression. Socio-demographic characteristics and clinical variables, medication adherence, psychological features (psychological reactance, health locus of control, and self-efficacy)
Isa et al. (2018)54 Nigeria Quantitative (Pre-post one-group intervention study) Outpatient 18 The purpose to investigate the effects of psycho-education and basic CBT intervention on depressed medication-treated adolescents. Depressive symptoms, knowledge of depression, hope, attitudes towards treatment adherence, and satisfaction
Klein et al. (2017)55 Netherlands Quantitative (Descriptive longitudinal study) Outpatient 289 The purpose to explore beliefs about the causes of depression and recovery and to examine whether they predict antidepressant medication use. Medication adherence, beliefs regarding depression, and antidepressant medication dosage
Lu et al. (2016)56 China Quantitative (Cross-sectional study) Outpatient 135 The purpose to investigate the variables associated with adherence with antidepressants in elderly Chinese patients, focusing on attitudes and beliefs as potential predictors, as well as sociodemographic characteristics and illness-related variables. Medication adherence and beliefs about medication
Lucca et al. (2015)57 India Quantitative (Cross-sectional study) Outpatient 400 (n=170 patients with depression) The purpose to determine the incidence and factors associated with medication nonadherence among psychiatric outpatients. Medication adherence and reasons for medication nonadherence
Novick et al. (2015)58 Six East Asian countries and regions (China, Hong Kong, Malaysia, Singapore, South Korea, and Taiwan) Quantitative (Cross-sectional study, prospective, observational study) Inpatient 430 The purpose to describe pharmacological treatment patterns in patients with MDD. Medication adherence, reasons for medication nonadherence, depressive symptoms, somatic symptom, and quality of life
Serrano et al. (2014)59 Spain Quantitative (Observational and longitudinal study) Outpatient 29 The purpose to determine the degree of therapeutic adherence in patients with depression, examine factors involved in the adherence process, and observe the clinical outcome. Medication adherence, depressive symptoms, drug attitude, beliefs about medication, and personality
Shrestha Manandhar et al. (2017)60 Nepal Quantitative (Prospective study) Inpatient and outpatient 60 The purpose to determine the medication adherence pattern in patients with depression and assess the factors associated with non-adherence to the prescribed antidepressant therapy. Medication adherence and medication adherence pattern
Taleban et al. (2016)61 Iran Quantitative (Randomized clinical trial) Outpatient 198 Booklet and text messaging group (67), booklet (66), and control (65) The purpose to evaluate the impacts of text messaging interventions, which aimed to inspire the affected patients to peruse bibliotherapy. Medication adherence and depression severity
Vannachavee et al. (2016)62 Thailand Quantitative (Randomized controlled trial with two parallel-group posttest-only designs) Outpatient 56 (30,26) The purpose to examine the effect of DAEP on adherence behaviors in patients with first diagnosed major depressive disorder. Medication adherence and depression severity
Bushnell et al. (2016)63 USA Quantitative (Retrospective cohort study) Inpatient and outpatient 8,837 The purpose to identify predictors of six-month antidepressant persistence. Antidepressant persistence, demographic, clinical, and psychosocial factors (age, sex, psychiatric and non-psychiatric co-morbidities, healthcare utilization, antidepressant class, prior suicide attempt, high and mid-potency prescription opiate usage, and recurrent MDD diagnosis)
Green et al. (2017)64 USA Mixed-method Outpatient 28 The purpose to investigate knowledge and attitudes about antidepressant medication, including risks and benefits, how patients received this information, and how they would prefer to learn about antidepressants. Medication persistence, knowledge and attitudes about antidepressant medication, Depression, Trauma exposure, post-traumatic stress disorder, and side effects
Grover et al. (2018)65 India Quantitative (Naturalistic, longitudinal, follow‑up study) Outpatient 140 The purpose to evaluate the medication adherence, treatment adherence, and outcome of depression. Medication adherence, treatment adherence, and outcome of depression
Holvast et al. (2019)66 Netherlands Quantitative (Longitudinal study) Outpatient 1,512 The purpose to determine the non-adherence rates to antidepressants among older adults in primary care, based on non-initiation, suboptimal implementation or non-persistence. Non-initiation, suboptimal implementation, non-persistence, associated with non-adherence
Klang et al. (2015)67 Israel Quantitative (Prospective, nonrandomized, open-label, naturalistic observational study) Outpatient 4246 (173, 4079) The purpose to effectiveness of CP intervention for patients with MDD. Medication adherence and depressive symptoms
LeBlanc et al. (2015)68
USA
Quantitative (Cluster randomized trial)
Outpatient
Clinicians (117); patients (297)
Clinicians (66, 51); patients (158, 139)
The purpose to estimate the effect of DMC on quality of the decision‐making process and depression outcomes.
Patient knowledge and involvement in decision making, patient and clinician decisional comfort and satisfaction, encounter duration, medication adherence, and depression symptoms
Slabbert et al. (2015)69 South Africa Quantitative (Prospective, descriptive cohort study) Outpatient 14,135 The purpose to investigate the prevalence of antidepressant non-compliance in the private healthcare sector of South Africa. Medication adherence
Zhang et al. (2016)70 China Quantitative (Retrospective cohort study) Inpatient and outpatient 8,484 The purpose to investigate medication usage patterns, health care resource utilization, and direct medical costs of patients with MDD in Beijing, People’s Republic of China. Medication usage patterns, health care resource utilization, and economic burden
Hammonds et al. (2015)71 USA Quantitative (Randomized, parallel-group clinical trial) Outpatient 57 (30, 27) The purpose to determine the effect of medication reminding via smartphone app on adherence to antidepressant medications in college students. Medication adherence, depression, social support, stress, and health beliefs
Pradeep et al. (2014)72 India Quantitative (Randomized trial) Outpatient 260 (122, 138) The purpose to investigate effectiveness of enhanced care in improving treatment seeking and adherence to antidepressant medication in women with depression living in rural India. Medication adherence, number of clinic visits, depressive symptoms, and quality of life
Srimongkon et al. (2018)73 Australia Qualitative (Phenomenological approach) Outpatient 23 The purpose to explore factors which facilitate and negatively impact adherence, at initiation, implementation and discontinuation phases of adherence to antidepressant medication. Facilitate and negatively impact adherence
Vargas et al. (2015)74 USA Qualitative (Ethnography) Outpatient 30 The purpose to examines salient views of depression and pharmacotherapy among Latinos seeking outpatient antidepressant therapy and suggests possible strategies for engaging patients on these views prior to the onset of treatment. Views of depression and antidepressant medication