Kiper Aslan

and 4 more

Objective: To determine the frequency of uterine abnormalities in PCOS patients compared to normo-ovulatory patients and their relationship to androgen levels. Design: Retrospective cohort study. Setting: Tertiary University Hospital Population: Total of 103 women, 51 PCOS, and 52 male factor infertility Interventions: HSG images of all patients were numbered and evaluated by ten senior reproductive endocrinologists blinded to the research and chose the most appropriate figure for each patient’s HSG image and marked the shape of cavity according to the ASRM and ESGE/ESHRE classification. Main outcome measures: Abnormal HSG Rates, serum AMH and androgen levels Results: The percentage of the normal uterine cavity was significantly lower in the PCOS group than control group as 51 % and 66.7 %, 77 % and 94.2 % according to the ASRM and ESHRE/ESGE classifications, respectively. The frequency of Partial Septate Uterus (ESHRE-ESGE U2a / ASRM Va, 21.6% vs 5.8 % p<0.05), Complete Septate Uterus (ESHRE-ESGE U2b / ASRM Vb, 7.8% vs 0% p<0.01) and Dysmorphic Uterus (ESHRE-ESGE U1c) / ASRM VII) 3.9 % vs 0 p<0.05) were significantly higher in PCOS patients than controls. The frequency of arcuate uterus classified as VI in ASRM and considered normal in ESHRE/ESGE was 16 % and 17.3 % in PCOS and control groups, respectively, without statistically significant difference. The increased frequency of intrauterine cavity abnormalities was correlated with serum-free testosterone levels. Conclusion: This study provides that the frequency of uterine cavity abnormality is clearly higher in PCOS patients compared to the healthy population.

Gurkan Uncu

and 4 more

Objective: To determine the incidence of uterine abnormalities in patients with PCOS Design: Retrospective Cohort Study Setting: Tertiary University Hospital Population: Infertile patients with PCOS vs. male factor infertility were selected from the IVF center electronic database from between the years 2011-2019. Methods: A total of 103 patients, 51 PCOS, and 52 male factor infertility were enrolled in the study. Hysterosalpingography (HSG) images of all patients were numbered. For the study, six different shapes of the intrauterine cavity were figured. All HSG images were evaluated by ten senior reproductive endocrinologists and surgeons. Seniors were blinded to the research and chose the most appropriate figure for each patient’s HSG image. Results and Demographic parameters were compared between PCOS and Male Factor Groups. Anti-Mullerian hormone correlation with Uterine abnormality was further analyzed. Main Outcome Measure: Percentage of the abnormal uterine cavity Results: The percentage of the normal uterine cavity was significantly lower in the PCOS group. (45.9 % and 73.1 %, p<0.01) The abnormal cavities were compared; Arcuate Uterus (22.18% vs 6.6% p<0.05), Partial Septate Uterus (5.1% vs 0% p<0.05), Complete Septate Uterus (5.47% vs 1.2% p<0.01) and Y-Shaped Uterus (7.47% vs 0 p<0.05) were significantly higher in PCOS patients. T-Shaped Uterus (13.8% vs. 18.9%) was statically similar. There was no correlation between serum AMH levels and the presence of uterine abnormality. Conclusion: This study provides that, compared to the healthy population, the uterine abnormality frequency is clearly higher Key Words: Polycystic Ovary Syndrome, Uterine Abnormality, Anti-Mullerian Hormone