Data Sources, Search Strategy, and Study Selection
Two reviewers searched MEDLINE (1990 to May 2020), EMBASE (1990 to May
2020), PUBMED (1990 to May 2020)
for randomized controlled studies
that compared any form of usage of NAC to placebo in adult patients (age
above 18) undergoing cardiac surgery. The following search terms were
employed to source for eligible studies: NAC, N-acetylcysteine, Cardiac
surgery, Cardiac surgical procedures, Cardiac, Heart, Renal, Kidney,
Acute Kidney Injury and Acute Renal failure. There was no language
restriction but only papers written in English were included.