Selection Process
Details of the flow of study identification are detailed in a Prisma chart shown in Figure 1. Database searches yielded a total of 277 citations after removing duplicate citations. 256 irrelevant citations were excluded based on abstract and title. After further assessment of the full text of the remaining citations, 11 were excluded due to not meeting the requirements of the selection criteria. These studies were excluded for the following reasons: studies reported only on serum creatine levels (n = 4), studies reported only on estimated glomerular filtration rate (n=2), studies reported on outcomes other than the incidence of acute kidney injury (n=2), studies reported on the usage of NAC in comparison to other drugs (n=2), studies reported on the usage of NAC with other drugs (n=1). Our analysis finally identified 10 eligible studies comprising 1,242 patients (623 NAC group; 619 control group) Characteristics of the included studies are summarized in Supplemental Table 1.