Prognostic value of metabolic parameters in baseline 18F-FDG PET/CT for
pediatric lymphoblastic lymphoma
Abstract
Purpose: This retrospective study aimed to evaluate the prognostic value
of metabolic parameters in baseline fluorine-18 fluorodeoxyglucose
positron emission tomography/computed tomography (18F-FDG PET/CT) for
pediatric lymphoblastic lymphoma (LBL). Method: Thirty patients with LBL
who underwent baseline 18F-FDG PET/CT from April 2013 to November 2018
were enrolled. Their metabolic parameters including maximum standardized
uptake value (SUVmax), total metabolic tumor volume (TMTV), and total
lesion glycolysis (TLG) were measured and compared with those from
different clinical characteristic groups. Event-free survival (EFS) and
overall survival (OS) curves were constructed using the Kaplan–Meier
method and compared with the log-rank test. Results: The patients with
stage Ⅳ had higher TMTV than stage Ⅲ (mean 580.66cm³ vs. 176.52cm³;
p=0.031). No statistical significance in SUVmax and TLG was observed
between patients with stages Ⅲ and Ⅳ (p=0.061; p=0.291). After a median
follow-up of 41.5 months (range of 1–86 months), the patients with a
low TMTV (<242.91cm³) had better 3-year EFS rate compared with
those with a high TMTV (88.9% vs. 56.3%; p=0.036). However, SUVmax and
TLG were not predictive of EFS(p=0.874; p=0.152). Conclusions: TMTV may
be a potential PET/CT metabolic parameter for predicting the prognosis
of pediatric lymphoblastic lymphoma. A high TMTV indicates a poor
outcome. However, SUVmax and TLG are not related to the prognosis of
pediatric lymphoblastic lymphoma.