3 GUT MICROBIOTA-MEDIATED DRUG HEPATOTOXICITY
Drug-induced liver injury (DILI) is one of the most common liver injuries hitherto. Despite the findings and progress mentioned above, little is known about gut microbiota in DILI. The gut-liver axis, jointing the two major metabolic organs, deserves attention in mechanistic study of DILI but it is only recently that gut microbiota is found to be engaged in it. So in the following part of this review, we will discuss existing researches and findings concerning gut microbiota in DILI by concentrating on its role in the initiation, progression, and hindrance of drug-related hepatotoxicity (Fig.3).