3 GUT MICROBIOTA-MEDIATED DRUG HEPATOTOXICITY
Drug-induced liver injury (DILI) is one of the most common liver
injuries hitherto. Despite the findings and progress mentioned above,
little is known about gut microbiota in DILI. The gut-liver axis,
jointing the two major metabolic organs, deserves attention in
mechanistic study of DILI but it is only recently that gut microbiota is
found to be engaged in it. So in the following part of this review, we
will discuss existing researches and findings concerning gut microbiota
in DILI by concentrating on its role in the initiation, progression, and
hindrance of drug-related hepatotoxicity (Fig.3).