Drug-Drug interaction (DDIs)
The detected potential DDIs were classified based on severity of interaction (31,32); 1) major DDI, which can cause life threating problem or severe damage to the patient. 2) Moderate DDI, which can cause some harm to the patient and affect his/her treatment, or his/her clinical status, and 3) mild DDI, which can cause insignificant harm to the patient, and usually unnoticeable. The potential DDIs were also categorised based on scientific evidence of interaction to (31,32); 1) Proven documentation, where the studies clearly established the existence of the interaction, 2) Good Documentation, where strongly suggest the presence of interaction, but controlled study are lacking, and 3) Fair documentation, where studies poorly suggest the interaction, but the clinicians suspect the interaction exists due to other factors. Prescriptions were screened for potential DDI using Micromedex Drug Reax© software (Thomson Reuters Inc., 2011). Micromedex provides fast and accurate checking on type, and severity of potential DDI (33).