Results
Of the 407 patients included, 954 drugs with risk of QTcP were
dispensed; 618 (64.8%) had interactions with other drugs; 10.4% were
major, 29.3% were moderate, and 60.3% were minor drug-drug
interactions. Absence of major polypharmacy and co-morbidity decreased
the odds of major drug-drug interactions by 61% (OR 0.61; 95% CI
0.23-0.97; p=0.02), and 72% (OR 0.72; 95% CI 0.44-1.23; p=0.04),
respectively. After clinical evaluation, 17.6% of the dispensed drugs
were considered inappropriate application, 12.9% were classified as
inappropriate choice, and 26.4% were judged as inappropriate decision.
Urology clinics were more likely to prescribe QTcP-inducing drugs based
on inappropriate decision.