Conclusions
This study provides further understanding of genetic influence from
allergen-specific IgE-level, but not blood eosinophils, on the
FENO asthma association. The results presented here shed
new light on the he clinical heterogeneity of FENOvalues in asthmatic children. As a next step this could encourage
omic-studies taking the allergen-specific IgE level into account when
investigating inflammation-markers in children with asthma.
Acknowledgments: Swedish Research Council grant no 2018-02640
and through the Swedish initiative for Research on Microdata in the
Social and Medical Sciences (SIMSAM) framework grant no 340-2013-5867,
grants provided by the Stockholm County Council (ALF-projects and
Funding for healthcare personnel), the Strategic Research Program in
Epidemiology at Karolinska Institutet, the Swedish Heart-Lung
Foundation, the Swedish Asthma and Allergy Association’s Research
Foundation, the Cancer and Allergy Foundation, Fredrik and Ingrid
Thuring’s Foundation, King Gustaf V 80th Birthday Foundation and
Stiftelsen Frimurare Barnahuset Stockholm. Competing financial
interests: M van Hage has received lecture fees from Thermo Fisher
Scientific.