Conclusions
This study provides further understanding of genetic influence from allergen-specific IgE-level, but not blood eosinophils, on the FENO asthma association. The results presented here shed new light on the he clinical heterogeneity of FENOvalues in asthmatic children. As a next step this could encourage omic-studies taking the allergen-specific IgE level into account when investigating inflammation-markers in children with asthma.
Acknowledgments: Swedish Research Council grant no 2018-02640 and through the Swedish initiative for Research on Microdata in the Social and Medical Sciences (SIMSAM) framework grant no 340-2013-5867, grants provided by the Stockholm County Council (ALF-projects and Funding for healthcare personnel), the Strategic Research Program in Epidemiology at Karolinska Institutet, the Swedish Heart-Lung Foundation, the Swedish Asthma and Allergy Association’s Research Foundation, the Cancer and Allergy Foundation, Fredrik and Ingrid Thuring’s Foundation, King Gustaf V 80th Birthday Foundation and Stiftelsen Frimurare Barnahuset Stockholm. Competing financial interests: M van Hage has received lecture fees from Thermo Fisher Scientific.