Figure 2 PET-CT images, BNP, HWI
and HE staining of myocardial sections of each group on the 7th and 14th
day after injection. A: PET-CT images showed high uptake on the 7th and
low uptake on the 14th day. (n=6) B: No obvious changes in BNP were
seen. (n=8) C: HE staining of myocardial sections showed some myocardial
cell destruction in 5-fluorouracil + bevacizumab group on the 14th day
after injection (objective × 10). 5-FU + BEV group: 5-fluorouracil +
bevacizumab group.
LVPW;d decreased on the
7th and 14th day and IVS;d, EF, FS decreased on the 14th day: As a
convenient method to detect the function and structure of the heart,
echocardiography was performed before injection and on the 4th, 7th and
14th days after injection to evaluate the changes of left ventricular
function and structure in mice. Before and the 4th, 7th and 14th days
after injection, there was no obvious cardiac echo change in the
echocardiogram of mice in each group. The mitral valve, tricuspid valve
and aortic valves were soft and well opened, and there was no obvious
reflux signal. There was no obvious change in the heart structure of
mice in each group. Compared with the control group, the IVS;d and
LVPW;d in the 5-fluorouracil + bevacizumab group became thinner with the
progress of the disease, and there was a statistical difference
(P <0.05) on the 14th day compared with the control
group. The LVID;d and LVID;s slightly
increased, but no statistical difference (P >0.05).
LVEF and LVFS decreased significantly on the 7th and 14th day compared
with the control group. This indicated that 5-fluorouracil and
bevacizumab had certain damage to the heart and had a certain
correlation with the dosage. As figure 3, part A-G.