2Corresponding author: Su Maolong, Email:
sumaolong@xmu.edu.cn
【Abstract】
Cardiotoxicity, including acute
and late-onset cardiotoxicity, was a well-known adverse effect of many
types of antitumor agents. Early identification of patients with
cardiotoxicity was important to ensure prompt treatment and minimize
toxic effects. This study compared the potential ability of multinomial
technique in early detection, prediction and combined diagnosis of
chemotherapy induced cardiotoxicity. We constructed a chemotherapy
induced cardiotoxicity model through intraperitoneal injection
bevacizumab and 5-fluorouracil in Balb/c mice. These mice were
administered with electrocardiogram, conventional echocardiography,
speckle tracking echocardiography, PET-CT, detection of B-type
natriuretic peptide, myocardial pathology. Compared with other cardiac
diagnose techniques, speckle tracking echocardiography and18F-FDG myocardial imaging can detect myocardial
injury in the early stage. The global longitudinal strain may provide a
noninvasive and accurate method for the early detection of
cardiotoxicity. The long axis longitudinal strain of left ventricular
first decreased in the apical segment of left ventricle. The long axis
radial strain of left ventricular first decreased in the posterior
segment of left ventricle. The short axis radial strain and
circumferential strain of left ventricular first decreased in the
anterior wall of left ventricle.
【Key words】 chemotherapy
induced cardiotoxicity; speckle tracking; preclinical mode
Fund program: Xiamen
Key Project of Medical and Health Sciences(3502Z20191103);