Figure 4 Global strain of left
ventricle long axis and short axis obviously decreased and global strain
rate of left ventricle long axis and short axis slightly decreased in
5-fluorouracil + bevacizumab group. (n=10) A: Long axis and short axis
strain and strain rate of each segment of left ventricle of each group.
B: GLS firstly decreased in 5-fluorouracil + bevacizumab group on
the
7th day. C: GLSR slightly decreased in 5-fluorouracil + bevacizumab
group with time. D: GRS of long axis obviously decreased in
5-fluorouracil + bevacizumab group the 14th day. E: GRSR of long axis
slightly decreased in 5-fluorouracil + bevacizumab group with time. F:
GCS obviously decreased in 5-fluorouracil + bevacizumab group the 14th
day. G: GCSR of long axis slightly decreased in 5-fluorouracil +
bevacizumab group with time. H: GRS of short axis decreased in
5-fluorouracil + bevacizumab group with time. I: GRSR of short axis
slightly decreased in 5-fluorouracil + bevacizumab group with time. 5-FU
+ BEV group: 5-fluorouracil + bevacizumab group. *: P <0.05. **:P <0.01.
The analysis of the strain
and strain rate of each segment of left ventricle: It can be seen that
the long axis radial strain of the posterior wall decreased on the 7th
day, while the radial strain of the anterior wall of the left ventricle
decreased on the 14th day. In the long axis longitudinal strain, the
strain of the apical segment decreased on the 7th day compared with the
control group, while the strain of the middle and basal segments
decreased on the 14th day compared with the control group potential. The
short axis radial strain in 5-fluorouracil + bevacizumab group was
significantly lower than that in the control group on the 7th and 14th
day, among which the left ventricular anterior wall, lateral wall,
posterior wall and inferior wall had statistical difference (P<0.05), but there was no statistical difference in the
interventricular septum (P >0.05). The short axis
circumferential strain of left ventricular anterior wall, anterior wall,
posterior wall and inferior wall was significantly lower on the 7th and
14th day than that in the control group. And there was significant
difference in the anterior wall of left ventricle (P<0.05). As figure 5 and 6.