Figure 4 Global strain of left ventricle long axis and short axis obviously decreased and global strain rate of left ventricle long axis and short axis slightly decreased in 5-fluorouracil + bevacizumab group. (n=10) A: Long axis and short axis strain and strain rate of each segment of left ventricle of each group. B: GLS firstly decreased in 5-fluorouracil + bevacizumab group on the 7th day. C: GLSR slightly decreased in 5-fluorouracil + bevacizumab group with time. D: GRS of long axis obviously decreased in 5-fluorouracil + bevacizumab group the 14th day. E: GRSR of long axis slightly decreased in 5-fluorouracil + bevacizumab group with time. F: GCS obviously decreased in 5-fluorouracil + bevacizumab group the 14th day. G: GCSR of long axis slightly decreased in 5-fluorouracil + bevacizumab group with time. H: GRS of short axis decreased in 5-fluorouracil + bevacizumab group with time. I: GRSR of short axis slightly decreased in 5-fluorouracil + bevacizumab group with time. 5-FU + BEV group: 5-fluorouracil + bevacizumab group. *: P <0.05. **:P <0.01.
The analysis of the strain and strain rate of each segment of left ventricle: It can be seen that the long axis radial strain of the posterior wall decreased on the 7th day, while the radial strain of the anterior wall of the left ventricle decreased on the 14th day. In the long axis longitudinal strain, the strain of the apical segment decreased on the 7th day compared with the control group, while the strain of the middle and basal segments decreased on the 14th day compared with the control group potential. The short axis radial strain in 5-fluorouracil + bevacizumab group was significantly lower than that in the control group on the 7th and 14th day, among which the left ventricular anterior wall, lateral wall, posterior wall and inferior wall had statistical difference (P<0.05), but there was no statistical difference in the interventricular septum (P >0.05). The short axis circumferential strain of left ventricular anterior wall, anterior wall, posterior wall and inferior wall was significantly lower on the 7th and 14th day than that in the control group. And there was significant difference in the anterior wall of left ventricle (P<0.05). As figure 5 and 6.