Experimental animals were divided into 3 groups;
Animals in the first group (Control group) were used as
controls, were administered a single dose of ip physiological saline
(PS) every day for thirty days and were euthanized at the end of the
month with lung tissue removed.
Animals in the second group (PPI group) had a single dose of ip
PPI (pantoprazole 40 mg, Sandoz/Turkey) administered every day for
thirty days and were euthanized at the end of the month with lung tissue
removed.
Animals in the third group (Ra Group) had a single dose of ip
H2 receptor blocker (Ranitidin 50 mg/2 ml, Deva/Turkey) administered
every day for thirty days and were euthanized at the end of the month
lung tissue removed.
Lung samples obtained in the study were assessed for histopathologic and
biochemical changes.