Immunogenicity effect on the residual level of the biologic
In the different group of our study, RA, SpA and CD, the presence of
ADAbs was inversely correlated to the trough levels of IFX and ADA.
Similar data have been reported in a large number of studies in the
literature [1,3,17,23-33].
The mechanisms involved in the decrease of the residual level of the
biologic are thought to be the formation of immune complexes between the
drug and ADAbs inducing acceleration of its clearance. In consequence,
we noticed a decrease in its bioavailability [14].