ADA and allergic reaction
In our study, the occurrence of allergic reactions was significantly
correlated with the presence of ADAbs and with a lower residual level.
Our data agree with several studies which have found that the presence
of ADAbs is a risk factor for allergic reactions [24,25]. A
meta-analysis with systematic review of the literature including 1185
IBD cases found that patients with anti-IFX ADAbs were 2 times more
likely to develop acute infusion reactions and 6 times more likely to
develop severe reactions [38]. Vande Casteele et al. demonstrated
that a low residual IFX level <2.2 μg/ml was associated with
the presence of allergic reactions in CD [39].