Association between clinical characteristics and PNI, NLR and
PLR in KD
The present study revealed the association between the
inflammation-based biomarkers and clinical features of KD, which are all
indicators of IVIG resistance (Table 2). The results revealed that
pretreatment PNI was significantly associated with age
(p =0.0448), PLT (p =0.0169) and serum sodium levels
(p =0.0163). The patients with low PNI tended to exhibit higher
levels of C-reactive protein (CRP) (p <0.0001) and a
higher the incidence of IVIG resistance (p =0.0042) when compared
with the patients with high PNI. Furthermore, high NLR was significantly
associated with low age (p =0.0285), platelet (p =0.0157)
and serum sodium levels (p =0.0086). A positive association
between NLR and CRP (p =0.0032), and the incidence of IVIG
resistance (p =0.0006) was detected in the present study.
Nevertheless, no significant associations were observed between the two
groups in terms of gender and total bilirubin level. In addition, high
PLR has been demonstrated to be associated with high levels of CRP
(p =0.0001), higher incidence of IVIG resistance (p =0.0116)
and with low age (p =0.0232). Nevertheless, no great differences
between PLR and gender, total bilirubin, PLT and serum sodium levels
were observed.
Notably, PNI was negatively correlated with
NLR (r =-0.4216;p <0.0001) and PLR (r =-0.4669,p <0.0001) (Fig. 2). Thus, the results of the present
study suggested that PNI was associated with other inflammatory
biomarkers in KD.