7-1. Clinical features
All clinical features of delayed HSRs have been reported with PPI.27 They can induce mild maculopapular eruption (MPE)71,72, fixed drug eruption (FDE)71,73 but also severe generalized bullous FDE (GBFDE)71, photosensitization with rabeprazole and esomeprazole,74 symmetrical drug-induced flexural exanthema (SDRIFE)47, DRESS71,75,76, acute generalized exanthematous pustulosis71,77,78 and TEN.71,79,80,81,82