Methods
In this single-center, retrospective cohort study, we included pediatric
cancer patients diagnosed at <18 years old between January
1994 and December 2014. Patients were included if they received
pulmonary toxic exposure: either chemotherapy (bleomycin, busulfan,
lomustine carmustine or cyclophosphamide) or thoracic radiation.
Outcomes included percent predicted values for spirometry, lung volumes,
and diffusion capacity of the lungs post-treatment.