Fig. 2. (A) Scheme of the experiments in the IntelliCage. Mice were subjected to experimental procedures that consisted of adaptation and learning phases. After adaptation phases (simple adaptation phase days 1-4 and nosepoke adaptation phase days 5-7, depicted as days 1-7) mice were subject to place preference learning (days 8-10) and reward-motivated discrimination learning (days 11-15). Results of place discrimination learning: (B) Number of nosepoke responses giving access to the bottle that contained tap water in preference learning, then sweetened water (10% sucrose) in reward-motivated discrimination learning (aligned by vertical dashed line with the timeline of experiment). The number of correct responses was corrected for the number of nosepokes to the bottle with tap water placed in the same corner. Values labelled with different letters differed from each other at p=0.05 (pairwise a-priori t-test with df=6). (D) Number of licks from the bottle that contained first tap then sweetened water in adaptation and training, respectively. (C) LTP recorded at the Shaffer correlates in the hippocampus. The time course of maximal EPSP slopes was normalized to baseline in the CA1 region of the hippocampus. Long-term potentiation was induced by high-frequency stimulation (HFS; 3× 100 Hz) of the Schaffer collaterals in slices from the H-BMR (orange squares, n=10), L-BMR (green triangle, n=8) and the RB mouse line (blue circles, n=7). The slopes labeled with different letters differed from each other at p=0.05 by the Tukey post-hoc test. (E) Representative traces of fEPSP 10 min before (black) and 15 and 90 min after (grey) the induction of LTP are shown. Scale bars = 2 mV and 5 ms.