<div>Abstract Objective: To compare the comprehensive developments between
children with large vestibular aqueduct syndrome (LVAS) and children
without LVAS and investigate the risk factors for developments of LVAS
children. Design: A retrospective propensity score matching analysis.
Setting: Beijing Children′s Hospital, Capital Medical University,
National Center for Children′s Health, Beijing, China. Method: 70
children with LVAS (41 boys, median of 28.50 months, range 6-72 months,
hearing threshold: 82.54±12.58 dB nHL) and 70 gender-, age-, and
auditory- matched overall children were recruited as LVAS and non-LVAS
group, respectively. The developments of children were assessed by
Gesell development schedules. Then the overall development and
sub-development results were compared between the two groups. Regression
analyses were used to assess the association between potential risk
factors and developments of LVAS subjects. Results: Compared with normal
developmental metrics, LVAS children and non-LVAS children both had
developmental delay (both P&lt;.001), which occurred not only in
verbal but also in non-verbal aspects (all P&lt;.05) except gross
motor in non-LVAS subjects. Whereas, the deaf children of two groups had
the similar performance including all sub-developments (all
P&gt;.05). For the developments of LVAS children, the age of
intervention was risk factor (B&lt;0, P&lt;.05) and the
developments of children older than 12 months was worse than those of
children younger than 12 months (P&lt;.05). Conclusion: Children
with LVAS had the equal developmental level in comparison with children
with same hearing impairments. Age of diagnosis was the risk factor for
developments of LVAS children and the obvious delay of developments
stared from 12 months.</div>