Cell
subtype
|
CR cells
n=5
|
CR cells
n=5
|
CCK cells
n=3
|
CCK cells
n=3
|
Pyramidal cells
n=5
|
Pyramidal cells
n=5
|
sIPSP Frequency (Hz) |
Control |
α5-SOP002 |
Control |
α5-SOP002 |
Control |
α5-SOP002 |
Wild-type |
1.52 ± 0.19 |
0.99 ± 0.14 |
1.12 ± 0.08 |
0.93 ± 0.01 |
1.18
± 0.05 |
0.80 ± 0.08 |
AppNL-F/NL-F |
2.94 ± 0.20 |
1.54 ± 0.10** |
0.87 ± 0.01 |
0.47 ± 0.11 |
0.80 ± 0.08 |
0.67 ± 0.04 |
sIPSP Amplitude (Hz) |
sIPSP Amplitude (Hz) |
sIPSP Amplitude (Hz) |
sIPSP Amplitude (Hz) |
sIPSP Amplitude (Hz) |
sIPSP Amplitude (Hz) |
sIPSP Amplitude (Hz) |
Wild-type |
1.41 ± 0.19 |
0.71 ± 0.07** |
0.59 ± 0.06 |
0.24 ± 0.02 |
1.01 ± 0.08 |
0.49 ± 0.06 |
AppNL-F/NL-F |
2.52 ± 0.23 |
1.10 ± 0.11** |
0.44 ± 0.03 |
0.21 ± 0.03* |
0.24 ± 0.03 |
0.12 ± 0.02** |
sEPSP Frequency (mV)
|
sEPSP
Frequency (mV)
|
sEPSP Frequency (mV)
|
sEPSP Frequency (mV)
|
sEPSP
Frequency (mV)
|
sEPSP Frequency (mV)
|
sEPSP Frequency (mV)
|
Wild-type |
1.8 ± 0.09 |
1.4 ± 0.09 * |
1.47 ± 0.15 |
1.8 ± 0.15 |
1.53
± 0.10 |
2.24 ± 0.20 |
AppNL-F/NL-F |
2.14 ± 0.26 |
2.52 ± 0.20 |
2.3
± 0.12 |
3.27 ± 0.18* |
3.14 ± 0.12 |
4.16 ± 0.12** |
sEPSP Amplitude (Hz) |
sEPSP Amplitude (Hz) |
sEPSP Amplitude (Hz) |
sEPSP Amplitude (Hz) |
sEPSP Amplitude (Hz) |
sEPSP Amplitude (Hz) |
sEPSP Amplitude (Hz) |
Wild-type |
0.74 ± 0.09 |
0.89 ± 0.05 |
0.62 ± 0.02 |
0.89 ± 0.06 |
0.77
± 0.06 |
1.20 ± 0.12 |
AppNL-F/NL-F |
0.99 ± 0.06 |
1.23 ± 0.05 |
0.86
± 0.05 |
1.83 ± 0.15** |
2.00 ± 0.09 |
2.96 ± 0.21** |