Figure 1. (A-C ) Optimisation of α5IA to α5-SOP002. (D)Detailed interactions of α5-SOP002 at the GABAAR binding site located at the interface between subunit α5 (blue) and γ2 (brown).(E) Surface representation of SH-AI-SOP002 (red) interacting with the α5 GABAAR at the α5 (blue) and γ2 (brown) subunits’ interface. (F) Upper view of the α5 GABAA subtype represented by ribbons. The red arrow points at α5-SOP002. Subunits α5 are shown in blue, β3 in green and γ2 in brown. (G) Surface and (H) ribbon representation of the α5 GABAAR.