Abstract: Objective: Investigate the relationship between the mastoid pneumatization and the paranasal sinus volumes in patients with unilateral chronic otitis media (COM) and make a contribution to understanding of COM etiopathogenesis. Methods:101 patients were divided into two groups: group 1, COM with isolated tympanic membrane perforation, consists of 51 patients and group 2, COM with cholesteatoma/retraction pocket, consists of 50 patients. Mastoid and sinus volumes were evaluated on preoperative temporal bone High-Resolution Computed Tomography (HRCT). Results: Sphenoid sinus volumes were significantly lower at the diseased side (p< 0.05), while there is no statistically difference in the maxillary and frontal sinus volumes. Also, the sphenoid sinus volumes significantly lower at the side of the ear with sclerotic mastoid than others (p<0.001). Conclusions: Long-standing childhood COM might restrict to pneumatization of the same sided sphenoid sinus considering the delayed development of the sphenoid sinus compared with other sinuses.

Objectives: Squamous cell carcinoma(SCC) is the most common laryngeal neoplasm. Squamous cell carcinoma variants (vSCC), on the other hand, show different clinical and pathological features than conventional type. The purpose of this study is to analyze the clinical and pathological findings of vSCC of the larynx. Methods: This retrospective study evaluates 110 patients diagnosed with vSCC in our institution between 2006-2017. Treatment of primary and recurrent diseases was evaluated. Overall survival, disease-specific survival and follow-up times were calculated as months. Difference between preoperative and postoperative pathology reports of surgically treated patients were compared. Results: There were 1497 patients diagnosed with laryngeal malignancy and 110 (7,34%) of these patients were diagnosed with vSCC. The most common pathological subgroup was verrucous carcinoma. The best prognosis was found in verrucous carcinoma and the worst was in spindle cell carcinoma. Overall survival rates was 90% and 54.7%, respectively. A group of patients had a preoperative pathological diagnosis, not vSCC, but conventional SCC with the incidence of 38.5-100% according to the histological subtype. This was most common in acantholytic carcinoma, followed by adenosquamous, basaloid and spindle cell carcinoma, respectively. Conclusions: Spindle cell carcinoma and basaloid type squamous cell carcinoma have the worst prognosis and the highest metastatic potential. Patients diagnosed with these two variants should be followed up more cautiously. It should also be kept in mind that the diagnosis of vSCC can be missed in patients diagnosed only with a small tissue biopsy sample.