Patient characteristics
Table 1 summarizes patient characteristics (n = 41). The
median age at diagnosis was 35 months (range = 8–75 months).MYCN was amplified in 23 patients, 39 patients had stage 4
disease, and the remaining 2 tumors showed MYCN amplification. An
INPC histologically unfavorable tumor was observed in 35 patients. Bone
and bone marrow were involved in 31 patients. The bone metastasis
frequency was higher in MYCN -amplified high-risk neuroblastoma
patients compared to MYCN -non-amplified high-risk neuroblastoma
patients.