Toxicity
During the assessment period post-HDC, grade 3 or 4 acute mucositis was
observed in 33 patients (grade 3, 32 patients; grade 4, 1 patient).
Capillary leak syndrome occurred in 8 patients, of which 4 patients
required intravenous steroid administration (grade 3). TMA occurred in 1
patient who required dialysis for grade 4 acute kidney injury and
finally died of grade 5 pulmonary hemorrhage 1 year post-HDC. In
addition, 2 patients died on days 22 and 57 after SCT, respectively
because of regimen-related toxicity; they developed grade 5 viral
infection (respiratory syncytial virus bronchiolitis in one and
cytomegalovirus pneumonia in the other). We also observed acute kidney
injury and hypertension in 3 patients (TMA, 1 patient; drug, 2
patients). None of the patients developed sepsis and SOS.