Toxicity
During the assessment period post-HDC, grade 3 or 4 acute mucositis was observed in 33 patients (grade 3, 32 patients; grade 4, 1 patient). Capillary leak syndrome occurred in 8 patients, of which 4 patients required intravenous steroid administration (grade 3). TMA occurred in 1 patient who required dialysis for grade 4 acute kidney injury and finally died of grade 5 pulmonary hemorrhage 1 year post-HDC. In addition, 2 patients died on days 22 and 57 after SCT, respectively because of regimen-related toxicity; they developed grade 5 viral infection (respiratory syncytial virus bronchiolitis in one and cytomegalovirus pneumonia in the other). We also observed acute kidney injury and hypertension in 3 patients (TMA, 1 patient; drug, 2 patients). None of the patients developed sepsis and SOS.